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Annual Report

A Leap Forward in Biomedical Technology that Surpasses Traditional

A Leap Forward in Biomedical Technology that Surpasses Traditional 
Bio-Tech 5-minute Test for Deadly Pathogens that Cause Septicemia and Bactermiea

The golden time for treating septicemia is 6 hours and bacteremia due to golden staph infection is 48 hours. There is now good news for acute septicemia and bactermeia patients! The "Ultra Rapid Diagnostic Chip for Detection of Pathogen from Human Blood" can now help doctors and pathologists quickly identify septicemia and bacteremia pathogens in just 5 minutes. The rapid detection of these deadly pathogens within the "golden time" enables the use of appropriate life-saving medication, reduces the mortality rates and also decreases the antibiotics abuse.

The "Ultra Rapid Diagnostic Chip for Detection of Pathogens from Human Blood" developed by the southern unit for the NDL requires just 5 minutes for whole cell testing. It does not require time-consuming and expensive processes such as cell rupturing for DNA testing, antibody modification or biochemical reactions. The three most common pathogens involved in bacteremia and septicemia (s. aureus., p. aeruginosa, e.coli) can now be successfully detected and identified through their spectrum signatures. Testing is possible even with a bacterial count of just a few thousand per millimeter. The research team led by Dr. Cheng I-fang was recognized with an award in the academic research category at the "9th National Innovation Awards".

Traditional techniques such as taking blood samples for culturing or biochemical testing can take days and involve complicated procedures with professional technicians. This testing technology developed by the NARL simplifies the testing process to realize the goal of "rapid testing and rapid decision-making". A single low-voltage source is all that's needed to isolate and concentrate the target bacteria (3 minutes), generating a high-density bacteria cluster. The concentrated bacteria on the slide can then be subjected directly to "Pathogen Spectral Fingerprinting" for testing and comparison (less than 2 minutes). The entire process can be completed in under 5 minutes. This method is simple, fast, low-cost and flexible. It can detect bacteria and special proteins in the blood in under 5 minutes to help physicians use the right drugs right away, greatly reducing mortality rates and patient suffering. This technology does not require biochemical procedures. 

Simple instructions are all that's necessary to carry out semi-automated testing.
This outstanding contribution of the NARL will greatly reduce biomedical testing time and costs. It has the potential to be developed into a compact testing instrument in the future and talks are now underway with multiple companies over technology transfers. Industry-academia collaboration should lead to rapid testing for biological molecules and viruses as well as increased sensitivity, elimination of interference during blood/blood sugar testing, rapid blood testing for viral infections and specific proteins, and other medical breakthroughs that offer tangible benefits. It will also assist local companies with enhancing the competitiveness of the biomedical industry.      

Ultra Rapid Diagnostic Chip for Detection of Pathogen from Human Blood
Group photo of Minister of Science and Technology Chang San-cheng and the R&D team from NDL at the "9th National Innovation Awards"